Dimerization of the kinase ARAF promotes MAPK pathway activation and cell migration

RAF kinases are direct RAS effector proteins and upon activation they trigger the classical MAPK signaling pathway that control various fundamental cellular processes. RAF family comprises of ARAF, BRAF and CRAF of which ARAF remains understudied.

In a cover story published this week in Science Signaling, Krishna Rajalingam's group demonstrate an obligatory role for ARAF kinase in mediating MEK1/2-ERK1/2 activation and tumour cell migration in a cell type dependent manner.

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