2018​

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• Kumaraswamy A, Mamidi A, Desai P, Sivagnanam A, Revathi Perumalsamy L, Ramakrishnan C, Gromiha M, Rajalingam K, Mahalingam S. The non-enzymatic RAS effector RASSF7 inhibits oncogenic c-Myc function. J Biol Chem. 2018 Aug 23. pii: jbc.RA118.004452. doi: 10.1074/jbc.RA118.004452.

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• Buehler U, Schulenburg K, Yurugi H, Šolman M, Abankwa D, Ulges A, Tenzer S, Bopp T, Thiede B, Zipp F, Rajalingam K. Targeting prohibitins at the cell surface prevents Th17-mediated autoimmunity. EMBO J. 2018 Jul 26. pii: e99429. doi: 10.15252/embj.201899429.

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• Wüstenhagen E, Boukhallouk F, Negwer I, Rajalingam K, Stubenrauch F, Florin L. The Myb-related protein MYPOP is a novel intrinsic host restriction factor of oncogenic human papillomaviruses. Oncogene. 2018 Jul 17. doi: 10.1038/s41388-018-0398-

 

• Imre G, Rajalingam K. Apoptosis inhibitor 5: Role in the inhibition of caspase-2. Cell Cycle. 2018 Feb 8:1-2. doi: 10.1080/15384101.2017.1415668. 

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• ​​Karthik IP, Desai P, Sukumar S, Dimitrijevic A, Rajalingam K, Mahalingam S. E4BP4/NFIL3 modulates the epigenetically repressed Ras effector RASSF8 function through histone methyl transferases. J Biol Chem. 2018 Feb 21. pii: jbc.RA117.000623. doi: 10.1074/jbc.RA117.000623. 

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2017​

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• ​​Murali A, Shin J, Yurugi H, Krishnan A,  Akutsu M, Carpy A, Macek B, Rajalingam K. Ubiquitin-dependent regulation of Cdc42 by XIAP. Cell Death Dis. 2017 Jun 29;8(6):e2900. doi: 10.1038/cddis.2017.305.

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• Yurugi H, Marini F, Weber C, David K, Zhao Q, Binder H, Désaubry L, Rajalingam K. Targeting prohibitins with chemical ligands inhibits KRAS-mediated lung tumours. Oncogene. 2017 Apr 17. doi: 10.1038/onc.2017.93. 

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• Imre G*, Berthelet J*, Heering J, Kehrloesser S, Melzer IM, Lee BI, Thiede B, Dotsch V, Rajalingam K. Apoptosis Inhibitor 5 is an endogenous inhibitor of caspase-2. EMBO Rep. 2017 DOI 10.15252/embr.201643744

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• Lacher SM, Bruttger J, Kalt B, Berthelet J, Rajalingam K, Wörtge S, Waisman A. HMG-CoA reductase promotes protein prenylation and therefore is indispensible for T-cell survival. Cell Death Dis. 2017 May 25;8(5):e2824. doi: 10.1038/cddis.2017.221.

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2016

 

• Rajalingam, K., Dikic, I. SnapShot: Expanding the Ubiquitin Code. Cell. 2016 Feb 25;164(5):1074-1074.e1. doi: 10.1016/j.cell.2016.02.019.

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• Liu X, Huai J, Endle H, Schlüter L, Fan W, Li Y, Richers S, Yurugi H, Rajalingam K, Ji H, Cheng H, Rister B, Horta G, Baumgart J, Berger H, Laube G, Schmitt U, Schmeisser MJ, Boeckers TM, Tenzer S, Vlachos A, Deller T, Nitsch R, Vogt J. PRG-1 Regulates Synaptic Plasticity via Intracellular PP2A/β1-Integrin Signaling. Dev Cell. 2016 Aug 8;38(3):275-90. doi: 10.1016/j.devcel.2016.06.019.

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• Shin J, Watanabe S, Hoelper S, Krüger M, Kostin S, Pöling J, Kubin T, Braun T. BRAF activates PAX3 to control muscle precursor cell migration during forelimb muscle development. Elife. 2016 Dec 1;5. pii: e18351. doi: 10.7554/eLife.18351.

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2015 

 

• Maus F, Sakry D, Binamé F, Karram K, Rajalingam K, Watts C, Heywood R, Krüger R, Stegmüller J, Werner HB, Nave KA, Krämer-Albers EM, Trotter J. The NG2 Proteoglycan Protects Oligodendrocyte Precursor Cells against Oxidative Stress via Interaction with OMI/HtrA2. PLoS One. 2015 Sep 4;10(9):e0137311. doi: 10.1371/journal.pone.0137311. eCollection 2015.

 

• Dubrez L, Rajalingam K. IAPs and cell migration. Semin Cell Dev Biol. 2015 Mar 10. pii: S1084-9521(15)00042-7. doi: 10.1016/j.semcdb.2015.02.015.

 

• Ulges A, Klein M, Reuter S, Gerlitzki B, Hoffmann M, Grebe N, Staudt V, Stergiou N, Bohn T, Brühl TJ, Muth S, Yurugi H, Rajalingam K, Bellinghausen I, Tuettenberg A, Hahn S, Reißig S, Haben I, Zipp F, Waisman A, Probst HC, Beilhack A, Buchou T, Filhol-Cochet O, Boldyreff B, Breloer M, Jonuleit H, Schild H, Schmitt E, Bopp T. Protein kinase CK2 enables regulatory T cells to suppress excessive TH2 responses in vivo. Nat Immunol. 2015 Mar;16(3):267-75. doi: 10.1038/ni.3083. Epub 2015 Jan 19.

 

• McEwan DG, Richter B, Claudi B, Wigge C, Wild P, Farhan H, McGourty K, Coxon FP, Franz-Wachtel M, Perdu B, Akutsu M, Habermann A, Kirchof A, Helfrich MH, Odgren PR, Van Hul W, Frangakis AS,Rajalingam K, Macek B, Holden DW, Bumann D, Dikic I. PLEKHM1 regulates Salmonella-containing vacuole biogenesis and infection.Cell Host Microbe. 2015 Jan 14;17(1):58-71. doi: 10.1016/j.chom.2014.11.011. Epub 2014 Dec 11.

 

 

2014

 

• Katharina Schulenburg, Gabor Glatz, Attila Remenyi, Krishnaraj Rajalingam (2014) 

  Divide and Rule: Role for ubiquitination in the inactivation of the ERK5-MAPK cascade. Mol Cel Oncol. Volume 1, Issue 4, 2014. DOI: 10.4161/23723548.2014.969170

 

• Mooz J, Oberoi-Khanuja TK, Harms GS, Wang W, Jaiswal BS, Seshagiri S, Tikkanen R, Rajalingam K. Dimerization of the kinase ARAF promotes MAPK pathway activation and cell migration.  Sci Signal. 2014 Aug 5;7(337):ra73. doi: 10.1126/scisignal.2005484.

 

• Winkler C, Doller A, Imre G, Badawi A, Schmid T, Schulz S, Steinmeyer N, Pfeilschifter J, Rajalingam K, Eberhardt W. Attenuation of the ELAV1-like protein HuR sensitizes adenocarcinoma cells to the intrinsic apoptotic pathway by increasing the translation of caspase-2L. Cell Death Dis. 2014 Jul 10;5:e1321. doi: 10.1038/cddis.2014.279.

 

• Takeda AN*, Oberoi-Khanuja TK*, Glatz G, Schulenburg K, Scholz RP, Carpy A, Macek B, Remenyi A, Rajalingam K. Ubiquitin-dependent regulation of MEKK2/3-MEK5-ERK5 signaling module by XIAP and cIAP1. EMBO J. 2014 Aug 18;33(16):1784-801. doi: 10.15252/embj.201487808. Epub 2014 Jun 28.

 

• Oberoi-Khanuja TK, Rajalingam K. Ubiquitination of Rac1 by inhibitors of apoptosis (IAPs). Methods Mol Biol. 2014;1120:43-54. doi: 10.1007/978-1-62703-791-4_4.

 

• Hornburger MC, Mayer BA, Leonhardt S, Willer EA, Zahler S, Beyerle A, Rajalingam K, Vollmar AM, Fürst R. A novel role for inhibitor of apoptosis (IAP) proteins as regulators of endothelial barrier function by mediating RhoA activation. FASEB J. 2014 Apr;28(4):1938-46. doi: 10.1096/fj.13-235754. Epub 2013 Dec 26.

 

 

2013

 

• Murali A, Rajalingam K. Small Rho GTPases in the control of cell shape and mobility. Cell Mol Life Sci. 2014 May;71(9):1703-21. doi: 10.1007/s00018-013-1519-6. Epub 2013 Nov 26. Review.

 

• Camargo Lde L, Babelova A, Mieth A, Weigert A, Mooz J, Rajalingam K, Heide H, Wittig I, Lopes LR, Brandes RP. Endo-PDI is required for TNFα-induced angiogenesis. Free Radic Biol Med. 2013 Dec;65:1398-407. doi: 10.1016/j.freeradbiomed.2013.09.028. Epub 2013 Oct 5.

 

• Yurugi H, Rajalingam K. A role for prohibitin in mast cell activation: location matters. Sci Signal. 2013 Sep 10;6(292):pe29. doi: 10.1126/scisignal.2004646.

 

• Oberoi-Khanuja TK, Murali A, Rajalingam K. IAPs on the move: role of inhibitors of apoptosis proteins in cell migration. Cell Death Dis. 2013 Sep 5;4:e784. doi: 10.1038/cddis.2013.311. Review.

 

• Jaiswal BS, Kljavin NM, Stawiski EW, Chan E, Parikh C, Durinck S, Chaudhuri S, Pujara K, Guillory J, Edgar KA, Janakiraman V, Scholz RP, Bowman KK, Lorenzo M, Li H, Wu J, Yuan W, Peters BA, Kan Z, Stinson J, Mak M, Modrusan Z, Eigenbrot C, Firestein R, Stern HM, Rajalingam K, Schaefer G, Merchant MA, Sliwkowski MX, de Sauvage FJ, Seshagiri S. Oncogenic ERBB3 mutations in human cancers. Cancer Cell. 2013 May 13;23(5):603-17. doi: 10.1016/j.ccr.2013.04.012.

 

• Tchoghandjian A, Jennewein C, Eckhardt I, Rajalingam K, Fulda S. Identification of non-canonical NF-κB signaling as a critical mediator of Smac mimetic-stimulated migration and invasion of glioblastoma cells. Cell Death Dis. 2013 Mar 28;4:e564. doi: 10.1038/cddis.2013.70.

 

 

2012

 

• Rajalingam K, Rudel T. "Prohibitin"g CRAF/MAPK activation with rocaglamides. Chem Biol. 2012 Sep 21;19(9):1077-8. doi: 10.1016/j.chembiol.2012.09.004.

 

• Imre G, Rajalingam K. Role for caspase-2 during pore-forming toxin-mediated apoptosis. Cell Cycle. 2012 Oct 15;11(20):3709-10. doi: 10.4161/cc.22046. Epub 2012 Sep 14. No abstract available.

 

• Oberoi-Khanuja TK, Rajalingam K. IAPs as E3 ligases of Rac1: shaping the move. Small GTPases. 2012 Apr-Jun;3(2):131-6. doi: 10.4161/sgtp.19988.

 

• Fulda S*, Rajalingam K*, Dikic I. Ubiquitylation in immune disorders and cancer: from molecular mechanisms to therapeutic implications. EMBO Mol Med. 2012 Jul;4(7):545-56. doi: 10.1002/emmm.201100707. Epub 2012 Jun 25. Review.

 

• Oberoi-Khanuja TK, Karreman C, Larisch S, Rapp UR, Rajalingam K. Role of melanoma inhibitor of apoptosis (ML-IAP) protein, a member of the baculoviral IAP repeat (BIR) domain family, in the regulation of C-RAF kinase and cell migration. J Biol Chem. 2012 Aug 17;287(34):28445-55. doi: 10.1074/jbc.M112.341297. Epub 2012 Jun 18.

 

• Imre G, Heering J, Takeda AN, Husmann M, Thiede B, zu Heringdorf DM, Green DR, van der Goot FG, Sinha B, Dötsch V, Rajalingam K. Caspase-2 is an initiator caspase responsible for pore-forming toxin-mediated apoptosis. EMBO J. 2012 May 30;31(11):2615-28. doi: 10.1038/emboj.2012.93. Epub 2012 Apr 24.

 

• Bull VH, Rajalingam K*, Thiede B*. Sorafenib-induced mitochondrial complex I inactivation and cell death in human neuroblastoma cells. J Proteome Res. 2012 Mar 2;11(3):1609-20. doi: 10.1021/pr200790e. Epub 2012 Feb 15.

 

• Amaddii M, Meister M, Banning A, Tomasovic A, Mooz J, Rajalingam K, Tikkanen R. Flotillin-1/reggie-2 protein plays dual role in activation of receptor-tyrosine kinase/mitogen-activated protein kinase signaling. J Biol Chem. 2012 Mar 2;287(10):7265-78. doi: 10.1074/jbc.M111.287599. Epub 2012 Jan 9.

 

• Bornstein B, Edison N, Gottfried Y, Lev T, Shekhtman A, Gonen H, Rajalingam K, Larisch S. X-linked Inhibitor of Apoptosis Protein promotes the degradation of its antagonist, the pro-apoptotic ARTS protein. Int J Biochem Cell Biol. 2012 Mar;44(3):489-95. doi: 10.1016/j.biocel.2011.12.005. Epub 2011 Dec 14.

 

• Oberoi TK*, Dogan T*, Hocking JC, Scholz RP, Mooz J, Anderson CL, Karreman C, Meyer zu Heringdorf D, Schmidt G, Ruonala M, Namikawa K, Harms GS, Carpy A, Macek B, Köster RW, Rajalingam K. IAPs regulate the plasticity of cell migration by directly targeting Rac1 for degradation. EMBO J. 2012 Jan 4;31(1):14-28. doi: 10.1038/emboj.2011.423. Epub 2011 Nov 25.

 

2011

 

• Imre G, Larisch S, Rajalingam K. Ripoptosome: a novel IAP-regulated cell death-signalling platform. J Mol Cell Biol. 2011 Dec;3(6):324-6. doi: 10.1093/jmcb/mjr034. Epub 2011 Nov 23.

 

• Rajalingam K, Dikic I. Healthy ageing through regulated proteostasis. EMBO J. 2011 Aug 3;30(15):2983-5. doi: 10.1038/emboj.2011.237. No abstract available.

 

• Rajalingam K, van der Goot FG. When cells and microbes meet in Krakow. EMBO Rep. 2011 Mar;12(3):188-90. doi: 10.1038/embor.2011.27. Epub 2011 Feb 25.

 

2010

 

• Lückerath K, Kirkin V, Melzer IM, Thalheimer FB, Siele D, Milani W, Adler T, Aguilar-Pimentel A, Horsch M, Michel G, Beckers J, Busch DH, Ollert M, Gailus-Durner V, Fuchs H, Hrabe de Angelis M, Staal FJ, Rajalingam K, Hueber AO, Strobl LJ, Zimber-Strobl U, Zörnig M. Immune modulation by Fas ligand reverse signaling: lymphocyte proliferation is attenuated by the intracellular Fas ligand domain. Blood. 2011 Jan 13;117(2):519-29. doi: 10.1182/blood-2010-07-292722. Epub 2010 Oct 22.

 

• Straub WE, Weber TA, Schäfer B, Candi E, Durst F, Ou HD, Rajalingam K, Melino G, Dötsch V. The C-terminus of p63 contains multiple regulatory elements with different functions. Cell Death Dis. 2010;1:e5. doi: 10.1038/cddis.2009.1.

 

2009

 

• Kozjak-Pavlovic V, Dian-Lothrop EA, Meinecke M, Kepp O, Ross K, Rajalingam K, Harsman A, Hauf E, Brinkmann V, Günther D, Herrmann I, Hurwitz R, Rassow J, Wagner R, Rudel T. Bacterial porin disrupts mitochondrial membrane potential and sensitizes host cells to apoptosis. PLoS Pathog. 2009 Oct;5(10):e1000629. doi: 10.1371/journal.ppat.1000629. Epub 2009 Oct 23.

 

• Morand PC, Drab M, Rajalingam K, Nassif X, Meyer TF. Neisseria meningitidis differentially controls host cell motility through PilC1 and PilC2 components of type IV Pili. PLoS One. 2009 Aug 31;4(8):e6834. doi: 10.1371/journal.pone.0006834.

 

• Kepp O, Gottschalk K, Churin Y, Rajalingam K, Brinkmann V, Machuy N, Kroemer G, Rudel T. Bim and Bmf synergize to induce apoptosis in Neisseria gonorrhoeae infection. PLoS Pathog. 2009 Mar;5(3):e1000348. doi: 10.1371/journal.ppat.1000348. Epub 2009 Mar 20.

 

• Rajalingam K, Dikic I. Inhibitors of apoptosis catch ubiquitin. Biochem J. 2009 Jan 1;417(1):e1-3. doi: 10.1042/BJ20082215.

 

• Fischer A, Baljuls A, Reinders J, Nekhoroshkova E, Sibilski C, Metz R, Albert S, Rajalingam K, Hekman M, Rapp UR. Regulation of RAF activity by 14-3-3 proteins: RAF kinases associate functionally with both homo- and heterodimeric forms of 14-3-3 proteins. J Biol Chem. 2009 Jan 30;284(5):3183-94. doi: 10.1074/jbc.M804795200. Epub 2008 Dec 2.

 

2008

 

• Dogan T, Harms GS, Hekman M, Karreman C, Oberoi TK, Alnemri ES, Rapp UR, Rajalingam K. X-linked and cellular IAPs modulate the stability of C-RAF kinase and cell motility. Nat Cell Biol. 2008 Dec;10(12):1447-55. doi: 10.1038/ncb1804. Epub 2008 Nov 16.

 

• Rajalingam K, Sharma M, Lohmann C, Oswald M, Thieck O, Froelich CJ, Rudel T. Mcl-1 is a key regulator of apoptosis resistance in Chlamydia trachomatis-infected cells. PLoS One. 2008 Sep 1;3(9):e3102. doi: 10.1371/journal.pone.0003102.

 

• Samoylenko A, Byts N, Rajalingam K, von Ahsen N, Rapp UR, Ehrenreich H, Sirén AL. Thrombopoietin inhibits nerve growth factor-induced neuronal differentiation and ERK signalling. Cell Signal. 2008 Jan;20(1):154-62. Epub 2007 Oct 12.

 

Before 2008

 

• Rajalingam K, Oswald M, Gottschalk K, Rudel T. Smac/DIABLO is required for effector caspase activation during apoptosis in human cells. Apoptosis. 2007 Aug;12(8):1503-10.

 

• Rajalingam K, Schreck R, Rapp UR, Albert S. Ras oncogenes and their downstream targets. Biochim Biophys Acta. 2007 Aug;1773(8):1177-95. Epub 2007 Jan 28. Review.

 

• Kepp O,* Rajalingam K*, Kimmig S, Rudel T. Bak and Bax are non-redundant during infection- and DNA damage-induced apoptosis. EMBO J. 2007 Feb 7;26(3):825-34. Epub 2007 Jan 18.

 

• Rajalingam K, Sharma M, Paland N, Hurwitz R, Thieck O, Oswald M, Machuy N, Rudel T. IAP-IAP complexes required for apoptosis resistance of C. trachomatis-infected cells. PLoS Pathog. 2006 Oct;2(10):e114.

 

• Paland N, Rajalingam K, Machuy N, Szczepek A, Wehrl W, Rudel T. NF-kappaB and inhibitor of apoptosis proteins are required for apoptosis resistance of epithelial cells persistently infected with Chlamydophila pneumoniae. Cell Microbiol. 2006 Oct;8(10):1643-55.

 

• Rajalingam K, Rudel T. Ras-Raf signaling needs prohibitin. Cell Cycle. 2005 Nov;4(11):1503-5. Epub 2005 Nov 1. Review.

 

• Rajalingam K, Wunder C, Brinkmann V, Churin Y, Hekman M, Sievers C, Rapp UR, Rudel T. Prohibitin is required for Ras-induced Raf-MEK-ERK activation and epithelial cell migration. Nat Cell Biol. 2005 Aug;7(8):837-43. Epub 2005 Jul 24.

 

• Machuy N, Thiede B, Rajalingam K, Dimmler C, Thieck O, Meyer TF, Rudel T. A global approach combining proteome analysis and phenotypic screening with RNA interference yields novel apoptosis regulators. Mol Cell Proteomics. 2005 Jan;4(1):44-55. Epub 2004 Nov 26.

 

• Machuy N, Rajalingam K, Rudel T. Requirement of caspase-mediated cleavage of c-Abl during stress-induced apoptosis. Cell Death Differ. 2004 Mar;11(3):290-300.

 

• Rajalingam K, Al-Younes H, Müller A, Meyer TF, Szczepek AJ, Rudel T. Epithelial cells infected with Chlamydophila pneumoniae (Chlamydia pneumoniae) are resistant to apoptosis. Infect Immun. 2001 Dec;69(12):7880-8.

 

• Krishnamurthy KV, Krishnaraj R, Chozhavendan R, and Christopher, F.S. (2000) The programme of cell death in plants and animals - A comparison. Current Science 79 (9): 1169-1181.

 

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