Prof. Dr. Gregory Harms

Head of Core Facility Microscopy

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My technical research interests are in Single Molecule Biophysics and Fluorescence Microscopy Techniques, including superresolution microscopy, deep tissue imaging by fluorescence microscopy and non-linear optical techniques, and my scientific research interests are in TGF-beta, Interleukin, and G-Protein coupled receptor signalling systems as drug targets to address cancer, inflammation and cardiovascular diseases and Alzheimer’s Disease neurodegeneration and Traumatic Brain Injury.  

 

 

EXPERIENCE

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1987 - 1992                B.A./B.S. Biophysical Chemistry & German, Bethel College, KS USA

 

1989-1990                  Exchange Student, Universität Marburg and Wuppertal,  Germany

 

1992-1998                  Ph.D. Biophysical Chemistry, University of Kansas, USA      

 

1997-1998                  Fulbright Scholar & Post-doc ETH Zürich (CH)

 

1998-2000                  Post-doctoral fellow, Universitaet Leiden (NL)Universität Linz (A)

 

2001-2002                  Post-doctoral Fellow, Pacific Northwest National Laboratory, USA

 

2002-2011                  Professor of Microscopy and Biophysics, Rudolf-Virchow-Center,

                                     Institut für Physik und Astronomie, Universität Würzburg, Germany 

2010-                           Associate Professor, Wilkes University, Departments ofBiology/Health                                                    Sciences and Physics/Engineering, USA

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SELECTED PUBLICATIONS

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• Mooz, J., Oberoi-Khanuja, T.K., Harms, G.S., Wang, W., Jaiswal, B.S., Seshagiri, S., Tikkanen, R., Rajalingam, K. (2014) Dimerization of ARAF promotes MAPK pathway activation and cell migration. Science Signaling 7, 337.

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• Brede, C., Friedrich, M., Jordán-Garrote, AL., Riedel, S., Bäuerlein, C., Heinze, K., Bopp, T., Schulz, S., Mottok, A., Kiesel, C., Mattenheimer, K., Ritz, M., von Krosigk, V., Rosenwald, A., Einsele, H., Negrin, R., Harms, G.S., Beilhack, A. (2012) Mapping immunological processes in intact organs at the single cell level. The Journal of Clinical Investigation 122(12):4439-46.

 

• Guzman A, Zelman-Femiak M, Boergermann JH, Paschkowsky S, Kreuzaler PA, Fratzl P,   Knaus P, Harms GS. (2012) SMAD versus non-SMAD signaling is determined by lateral mobility of bone morphogenetic protein (BMP) receptors. J. Biol Chem. 49(2), 574-579.

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• Oberoi TK, Dogan T, Hocking JC, Scholz RP, Mooz J, Anderson CL, Karreman C, Meyer Zu    Heringdorf D, Schmidt G, Ruonala M, Namikawa K, Harms GS, Carpy A, Macek B, Köster RW, Rajalingam K. (2011) IAPs regulate the plasticity of cell migration by directly targeting Rac1 for degradation. EMBO Journal  31 (1), 14 – 28.

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• Ermolayev, V., Friedrich, M., Nozadze, R., Cathomen, T., Klein, M.A., Flechsig, E. and Harms, G.S. (2009)  Ultramicroscopy reveals axonal transport impairments     in         cortical motor neurons at prion disease. Biophys J, 96 (8), 3390-3398.

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• Dogan,T., Harms, G.S., Hekman, M., Karremann, C.,  Alnemri, E.S., Rapp, U.R. and       Rajalingam, K. (2008) X-linked and cellular IAPs modulate the stability of C-RAF kinase and cell motility, Nature Cell Biol., 10(12), 1447 – 1455.

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• Gromova, K., Friedrich, M., Noskov, A., Harms, G.S. (2007) Visualizing SMAD1/4 signaling response to Bone Morphogenetic Protein-4 activation by FRET biosensors. BBA Mol. Cell  Res, 1773, 1759-1773.

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• Friedl, P, Wolf, K., von Andrian, U., Harms, G.S. (2007) Biological second and third harmonic generation microscopy. Curr Prot Cell Biol, 4.15.1-4.15.21. 7

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• Vilardaga, J.P., Steinmeyer, R., Harms, G.S., Lohse, M.J. (2005) Molecular basis of inverse agonism in a G protein-coupled receptor. Nat Chem Biol, 1, 25-28. 6