Dr. Inga Maria Melzer

Scientific Administration and Coordination

 

Inga Melzer was born in Braunschweig and grew up in Northern Germany. She received her Diploma in Biochemistry from the University of Hamburg and did her PhD thesis in Applied Research in Parasitology and Cell Signalling at the Bernhard-Nocht-Institut in Hamburg. In 2007 she moved to Frankfurt am Main to take up a Postdoctoral Researcher position with Prof. Dr. Martin Zörnig at the Georg Speyer Haus where she stayed until 2013, working on the characterization of the antiapoptotic protein AVEN especially in the context of blood and breast cancer development. Inga started her work as a Scientific Coordinator/Administrator in Prof. Rajalingam´s group in January 2015.  She is in charge of  all animal experimental work in the lab. Inga is the mother of one child, Leni, who was born in 2013.

 

 

 

PROFESSIONAL CAREER

 

01/2015- present   Scientific Coordinator/Administrator AG Prof. Dr. Rajalingam,                                              Unimedizin Mainz

 

12/2007-12/2013  Postdoctoral Scientist AG Prof. Zörnig, Georg Speyer Haus,

                                 Frankfurt am Main

 

03/2007-06/2007  Postdoctoral Scientist AG Dr. Wiese, Bernhard-Nocht-Institut,                                                Hamburg

 

EDUCATION

 

 04/2003-03/2007  PhD thesis, Bernhard-Nocht-Institute, Hamburg: Characterization of                                   LmxMPK1, an essential MAP Kinase of Leishmania Mexicana,                                               Magna cum laude.

 

10/1997-10/2002   Studies in Biochemistry/Molecular Biology, University of Hamburg,                                    Diploma thesis: Characterization of Lipases from Candida albicans

 

 

PUBLICATIONS

 

Eißmann M, Schwamb B, Melzer IM, Moser J, Siele D, Köhl U, Rieker RJ, Wachter DL, Agaimy A, Herpel E, Baumgarten P, Mittelbronn M, Rakel S, Kögel D, Böhm S, Gutschner T, Diederichs S, Zörnig M. (2013). A functional yeast survival screen of tumor-derived cDNA libraries designed to identify anti-apoptotic mammalian oncogenes. PLoS One. 2013 May 22;8(5):e64873.

 

Eißmann, M*, Melzer, IM*, Mateus-Fernández, SB, Michel, G, Hrabě de Angelis, M, Hoefler, G, Finkenwirth, P, Jauch, A, Schoell, B, Grez, M, Schmidt, M, Bartholomae, CC, Newrzela, S, Rieger, MA, Haetscher, N, Zachskorn, C, Mittelbronn, M, and Zörnig, M. (2013). Overexpression of the antiapoptotic protein AVEN cotributes to increased malignancy in hematopoietic neoplasms. Oncogene. May 16; 32(20):2586-91. Epub 2012 Jul 2.

(* equal contribution)

 

Melzer IM*, Mateus Fernández SB*, Bösser S, Lohrig K, Lewandrowski U, Wolters D, Kehrloesser S, Brezniceanu ML, Theos AC, Irusta PM, Impens F, Gevaert K, Zörnig, M. (2012). The Apaf-1-binding protein Aven is cleaved by Cathepsin D to unleash its anti-apoptotic potential. Cell Death Differ., Sep;19(9):1435-45. Epub 2012 Mar 2.

(* equal contribution)

 

Lückerath K, Kirkin V, Melzer IM, Thalheimer FB, Siele D, Milani W, Adler T, Aguilar Pimentel A, Horsch M, Michel G, Beckers J, Busch DH, Ollert M, Gailus-Durner V, Fuchs H, Hrabě de Angelis M, Staal FJT, Rajalingam K, Hueber AO, Strobl LJ, Zimber-Strobl U, Zörnig M. (2011) Immune modulation by Fas Ligand reverse Signaling: Lymphocyte proliferation is attenuated by the intracellular Fas Ligand domain. Blood; 117: 519-29.

 

Guardiola-Serrano F., Rossin, A., Cahuzac, N., Lückerath, K., Melzer, I., Malfert, D., Marguet, S., Zörnig, M., Hueber, A.O. (2010). Palmitoylation of human FasL modulates its cell death-inducing function. Cell Death Dis. Oct 21;1(10):e88.

 

Von Freyend SJ, Rosenqvist H, Fink A, Melzer IM, Clos J, Jensen ON, Wiese M (2010). LmxMPK4, an essential mitogen-activated protein kinase of Leishmania mexicana is phosphorylated and activated by the STE7-like protein kinase LmxMKK5. Int J Parasitol. 40(8):969-78.

 

Erdmann, M., Scholz, A., Melzer, I.M., Schmetz, C., and Wiese, M. (2006) Interacting Protein Kinases Involved in the Regulation of Flagellar Length, Mol Biol Cell, 17(4):2035-45.

 

Wang, Q. *, Melzer, I.M.,* Kruse, M., Sander-Juelch, C., and Wiese, M. (2005) LmxMPK4, a mitogen-activated protein (MAP) kinase homologue essential for promastigotes and amastigotes of Leishmania mexicana, Kinetoplastid Biol Dis, Dec 29th, 4:6 (* equal contribution)

 

Kunze, D., Melzer, I., Bennett, D., Sanglard, D., MacCallum, D., Nörskau, J., Coleman, D.C., Odds, F.C., Schäfer, W., Hube, B. (2005). Functional analysis of the phospholipase C gene CaPLC1 and two unusual phospholipase C genes, CaPLC2 and CaPLC3, of Candida albicans. Microbiology. 2005 Oct;151(Pt 10):3381-94.

 

 

PRIZES, GRANTS AND FELLOWSHIPS

 

2015                        Selected member of the Edith Heischkel Mentoring Programme for
                                 female researchers at Unimedizin Mainz

 

07/2012-12/2013   LOEWE CGT Startup Grant, Center for Cell and Gene Therapy,

                                 Uniklinikum Frankfurt

 

12/2011                   Paul-Ehrlich Förderpreis 2011, awarded by the Association of
                                  Friends and Supporters of the Georg Speyer Haus

 

10/2011                   DAAD "Vortragsreisen" travel grant for invited oral presentation in

                                 the lab of Associate Professor Dr. Pablo Irusta, Georgetown
                                 University, Washington DC, USA

 

10/2011                  Travel grant Glaxo Smith Kline foundation for the Cell Death
                                Meeting 2011, Cold Spring Harbor, NY, USA

 

09/2011                  ECDO travel scholarship, ECDO conference 2011, Stockholm

 

09/2010                  ECDO travel scholarship, ECDO conference 2010, Ghent