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Dr. Gergely Imre

PostDoc

 

Gergely Imre was born in Budapest, Hungary. He spent the school years in Budapest, where he received MSc degree in Molecular biology. 
He joined Ph.D program at the 1st Institute of Pathology and Experimental Cancer Research, Semmelweis Medical School, Budapest, under the supervision of Dr. Rudolf Mihalik. 
During his doctoral studies he worked on better understanding of the alternativ pathways of cell death regulation in cancer cells. 
After completing the Ph. D, he joined Dr. Krishnaraj Rajalingam's laboratory at the Institute of Biochemistry II, Goethe University, Frankfurt am Main. 
His current research interest is focused on the molecular regulation of cell death pathways in pathological processes such as bacterial infections and cancer.

 

 

EDUCATION

  

2003-2008          Ph.D. student at the Doctoral School of Pathological Sciences and                                               Oncology, Semmelweis University, Budapest, Hungary

 

2002-2004          MSc in Secondary Teacher's Qualifications (Biology) Eötvös Loránd                                           University,Budapest, Hungary

 

1998-2003          MSc in Molecular Biology Eötvös Loránd University, Budapest, Hungary

  

 

PUBLICATIONS

 

  • Imre G, Heering J, Takeda AN, Husmann M, Thiede B, zu Heringdorf DM, Green DR, van der Goot FG, Sinha B, Dötsch V, Rajalingam K. Caspase-2 is an initiator caspase responsible for pore-forming toxin-mediated apoptosis. EMBO J. 2012; 31(11):2615-28.

 

  • Winkler C, , Doller A, Imre G, Schmid T, Schulz S, Rajalingam K, Pfeilschifter J, Badawi A, and Steinmeyer N, Eberhardt W. Attenuation of the ELAV1-like protein HuR sensitizes adenocarcinoma cells to the intrinsic apoptotic pathway by increasing the translation of caspase-2L. Cell Death and Disease 2014; accepted for publication on 19th May 2014, ahead of print

 

  • Imre G, Rajalingam K. Role for Caspase-2 during pore-forming toxin-mediated apoptosis. Cell Cycle. 2012;11(20):3709-10

 

  • Dunai ZA, Imre G, Barna G, Korcsmaros T, Petak I, Bauer PI, Mihalik R. Staurosporine Induces Necroptotic Cell Death under Caspase-Compromised Conditions in U937 Cells. PLoS One. 2012;7(7):e41945.

 

  • Imre G, Larisch S, Rajalingam K. Ripoptosome: a novel IAP-regulated cell death-signalling platform. J Mol Cell Biol. 2011;3(6):324-6.

 

  • Imre G, Dunai Z, Petak I, Mihalik R. Cystein cathepsin and Hsp90 activities determine the balance between apoptotic and necrotic cell death pathways in caspase compromised U937 cells. Biochim Biophys Acta MCR 2007; 1773(10):1546-57.

 

  • Mihalik R, Imre G, Petak I, Szende B, Kopper L. Cathepsin B-independent abrogation of cell death by CA-074-OMe upstream of lysosomal breakdown. Cell Death Differ 2004;11(12):1357-60.

 

  • Felfoldi B, Imre G, Igyarto B, Ivan J, Mihalik R, Lacko E, Olah I, Magyar A. In ovo vitelline duct ligation results in transient changes of bursal microenvironments. Immunology 2005;116(2):267-75.

 

  • Nagy K, Petak I, Imre G, Barna G, Gezane-Csorba M, Sebestyen A, Houghton JA, Mihalik R, Kopper L. Proteasome inhibitors abolish cell death downstream of caspase activation during anti-microtubule drug-induced apoptosis in leukemia cells. Anticancer Res 2005;25(5):3321- 

 

  • Mihalik R, Imre G. Kaszpázok, apoptózis, sejtelhalás: (jel)útvesztÅ‘ben. Orvosképzés 2006, LXXXI. évfolyam, 3. szám: 151-157

 

INTERNATIONAL PRIZES

 

2008  EMBO poster award

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